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Figure 2 | EURASIP Journal on Bioinformatics and Systems Biology

Figure 2

From: The Impact of Time Delays on the Robustness of Biological Oscillators and the Effect of Bifurcations on the Inverse Problem

Figure 2

Eigenvalues of the Jacobian matrix correspond to intersections of the two function and . This Figure illustrates how a stable fixed point is destabilized by a time delay Ï„. (a) For , is a constant function, and the Jacobian matrix has two negative real eigenvalues and . (b) For , the function is a strictly increasing function that approaches 0 exponentially. Thus, increasing Ï„, the two real eigenvalues coalesce to a pair of complex conjugate eigenvalues, whose real parts eventually become positive. (c) A further increase in Ï„ leads to a new osculation point of and at a value . This is positive and real, and hence corresponds to an unstable fixed point. (d) For , the two eigenvalues approach the values and .

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