Identification of Th1/Th2 regulatory switch to promote healing response during leishmaniasis: a computational approach

EURASIP Journal on Bioinformatics and Systems Biology

Table 1 Unique combinations of proteins that can be used as promising immunotherapeutic targets

Knock-in	Knock-out	Th1 response up-regulation	NO increase	Th2 response down-regulation	Anti-Leishmania Immunity^b	Figure
IL12^a	–	Yes	No	Yes	No	6c
IFN_GAMMA_T^a	–	Yes	No	Yes	No	6d
MKP_T	–	No	No	Yes	No	6e
TLR3	–	No	Yes	No	No	6f
–	SHP2_T	Yes	No	Yes	No	6g
–	SHC_T	No	No	No	No	6h
–	TLR2	Yes	Yes	Yes	Yes	6i
TLR3^c	SHP2_T^c	Yes	Yes	Yes	Yes	6j
TLR3, MKP_T^d	SHC_T^d	Yes	Yes	Yes	Yes	6k

^arepresents previously known and commonly used immunotherapeutic targets; ^brepresents anti-Leishmania immunity that implies to a state when Th1 and NO response is up-regulated and the Th2 response is down-regulated; ^crepresents the proposed Combination 1; ^drepresents the proposed combination 2 treatment strategy